Expression profiling data (Figure 5 A) and validation by qPCR (Figure 5 B) revealed that among the top upregulated genes were target genes with well-documented tumor-promoting activities such as matrix metalloproteinases, e.g. MMP7 and MMP9, chemokine receptors such as IL-7R, and proangiogenic and proinflammatory factors such as VEGFA, and IL-8 (Table 1, Figure 5, figure S3). This evidence concerns the gene MMP9 and neoplasm.