Several human studies report increased total and Sar s 14.3 specific IgE in scabies [9], [25], [32], and the development of a Sar s 14 ELISA for human scabies has focussed on detection of IgE, rather than the more commonly utilised IgG, which was considered a less specific marker of infection [32], [33]. Here, IGHE is linked to infection.