The poor cytotoxic activity against colon CICs was not an intrinsic feature of the Vγ9Vδ2 T cells, because the differentiated colon cancer cell lines DLD-1, SW620, SW403, CDC#3 and CDC#4 were efficiently killed by two Vγ9Vδ2 T cell lines COLD2-1 and COLD2-2 obtained from two different colon cancer patients (P#3 and P#4) (Figure 2A), as well as Vγ9Vδ2 T cell lines obtained from healthy subjects (data not shown). This evidence concerns the gene FBXW7 and malignant colon neoplasm.