Overexpression of Sirt1 also protected neurons from mutant Htt-mediated toxicity via the deacetylation of FOXO3a, a pro-survival factor [26], or via the deacetylation of TORC1, a brain-specific modulator of CREB activity [27], in a mouse model of HD. The gene discussed is CRTC1; the disease is Huntington disease.