Consistent with a recent study showing that miR-99a directly targets and regulates mTOR in childhood adrenocortical tumors [41], we found that forced expression of miR-99a suppressed luciferase activity of the wild type, but not the mutant mTOR reporter (Fig. 2A) and mTOR expression at protein level (Fig. 2B). Here, MTOR is linked to adrenal cortex neoplasm.