AKT1 and acute promyelocytic leukemia: Modulators of the PI3K/Akt signaling pathway including PTEN [1], [2], PML (promyelocytic leukemia) [3], TSC [4] and Fbxw7 [5], [6] and effectors including FoxO transcriptional factors [7], [8], [9] and p21Cip [10] are indispensible for the homeostasis of normal hematopoietic stem cells (HSCs), implying that abnormal activation of Akt negatively regulates HSC stemness.