AMH and polycystic ovary syndrome: Hyperinsulinaemia has been proposed as a possible mechanism that may disrupt normal follicular development, [50] with polycystic ovary syndrome associated with both hyperinsulinaemia and marked increases in AMH, [20], [25] however in the current study we did not see an association between AMH and insulin, and there was also no evidence of a non-linear association suggestive of a threshold effect.