The extracts from several traditional Chinese herbs such as Astragalus membranaceus [100], Paeonia suffruticosa [101], Magnolia officinalis [102], and Rhizoma anemarrhenae [103] were reported to effectively prevent memory impairment via downregulation of the expression or activity of BACE1, thereby reducing APP levels in animal models. The gene discussed is BACE1; the disease is memory impairment.