The present study was designed to investigate antidiabetic effects and possible mechanisms of TLSP, LSP1, and LSP2 by using KKAy mouse model which is an excellent genetically diabetic model characterized by insulin resistance, hyperglycemia, hyperinsulinemia, and hyperlipaemia that closely resemble obesity-linked type 2 diabetes in humans [41, 42]. This evidence concerns the gene KLK11 and hyperinsulinism.