Furthermore, following depletion of FoxP3+ T cells, DCs that lack the expression of MHC class II molecules were not able to make cognate interactions with CD4+ T cells resulting in spontaneous and fatal CTL-mediated autoimmunity, indicating the critical suppressive role of the FoxP3+ Treg population in maintaining DCs in a tolerogenic state [67]. The gene discussed is FOXP3; the disease is Autoimmunity.