Though tumors cells may produce such mediators, also tumor-infiltrating leukocytes may be their source, and, indeed, the study of such populations has revealed that regulatory Foxp3+ T cells (Tregs) [28], anti-inflammatory M2-macrophages [29], plasmacytoid dendritic cells (pDCs) [30], and immature myeloid DCs [31] accumulate in human neoplastic tissues and patients' blood [4] and have been associated with poor prognosis for the patients specific cancer types. The gene discussed is FOXP3; the disease is neoplasm.