Consistent with these studies, Besner and colleagues have examined the role of E-cadherin and integrins in NEC, and have determined that the growth factor heparin bound epidermal growth factor (HB-EGF) can promote intestinal restitution in NEC through effects on integrin-extracellular matrix interactions and intercellular adhesions [16]. The gene discussed is EGF; the disease is necrotizing enterocolitis.