Glucose transporters, or key enzymes as hexokinase II (HKII), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), lactate dehydrogenase (LDH) and the isoform M2 of pyruvate kinase (PKM2) are upregulated in cancer cells and accordingly suggested as potential therapeutic targets [8, 9]. The gene discussed is HK2; the disease is cancer.