In vivo experiments have also shown PCBs to increase metastasis by triggering the production of reactive oxygen species (ROS), thereby activating the Rho-associated protein kinase (ROCK) signaling pathway [66] or vascular endothelial growth factor (VEGF) overexpression that stimulates endothelial hyperpermeability and transendothelial migration of cancer cells [67]. Here, VEGFA is linked to cancer.