TNF and coronary artery disorder: It has been shown that EAT produces inflammatory mediators such as interleukin (IL)-6, IL-1b, tumor necrosis factor (TNF)-a, and monocyte chemotactic protein (MCP-1) in patients with significant coronary artery disease [22] and expresses mRNAs of adiponectin, resistin, leptin, IL-6, TNF-a, and CD-45 [23].