Notably, viral infection is prone to disrupt PML-NBs and delocalizes the components of PML-NBs (Puvion-Dutilleul et al., 1995a,b; Doucas et al., 1996; Korioth et al., 1996; Ahn and Hayward, 1997, 2000; Bell et al., 2000a,b). The gene discussed is PML; the disease is viral infectious disease.