CD49f and SSEA4 along with other surface markers, such as CD24, CD44, CD133, have been commonly used for the detection of CSCs in solid tumors, including human breast, brain, colon, and ovarian cancer (Zhou et al., 2009), as well as for categorizing breast cancer molecular subtypes (Hergueta-Redondo et al., 2008; Nakshatri et al., 2009; Stagg and Pommey, 2009). This evidence concerns the gene PROM1 and breast cancer.