Among these derivatives, 13,14-bis(cis-3,5-dimethyl-1-piperazinyl)-β-elemene (IIi) was found to be one of the most potent agents for inhibiting the proliferation of human cancer cells and it also demonstrated an inhibitory effect on mTOR (8) The structures of β-elemene and IIi are shown in Fig. 1A. Here, MTOR is linked to cancer.