Sham treated IL-10 deficient mice (Sham-Co) kept in the conventional environment developed severe enterocolitis manifested with moderately severe pathological lesions (score 2.4 ± 0.3) including infiltration of inflammatory and immune cells lamina propria, ulceration, and rectal prolapse when compared to those control littermates kept in transgenic environment (0.3 ± 02, data not clown). Here, IL10 is linked to enterocolitis.