To our knowledge this is the first report indicating: (a) GrTP to preserve gut microstructure and to protect against enterocolitis in IL-10 deficient model; (b) High dose EGCG consumption to provoke exaggerated global antioxidants and excess weight loss, rendering ineffective against colitis; (c) GrTP and Low dose EGCG to protect against colitis similar to the standard-of-care sulfasalazine, and to improve anemia. This evidence concerns the gene IL10 and colitis.