Clinically, association of inflammation with NAFLD was confirmed by the fact that patients with NAFLD have elevated levels of TNFα (Jarrar et al., 2008) and expression of TNFα and TNFα receptor are upregulated in the livers of the patients with NAFLD compared to healthy individuals (Feldstein et al., 2004). The gene discussed is TNF; the disease is metabolic dysfunction-associated steatotic liver disease.