GH1 and neoplasm: Growth hormone is a mitogen, however, and despite several studies that show no demonstrated increased risk of malignancy with GHRT, the use of GH is contraindicated in active malignancy out of concern it might accelerate the growth of an existing neoplasm (Frajese et al., 2001; Hatrick et al., 2002; Chung et al., 2005, 2008; Jostel et al., 2005; Karavitaki et al., 2006; Buchfelder et al., 2007; Arnold et al., 2009; Olsson et al., 2009).