INS and metabolic syndrome: In fact, some studies of titrated GH replacement for AGHD have been shown to improve insulin sensitivity, at least in patients with features consistent with metabolic syndrome (Johannsson et al., 1997b), suggesting that improved body composition can at least partially counter the direct anti-insulin actions of GH, although in non-obese subjects the net effect of GH treatment is usually a mild increase in fasting glucose and/or insulin within the normal range.