Chronic exposure to alcohol decreases the levels of brain nociceptin/orphanin FQ (Lindholm et al., 2002), and activation of the nociceptin/orphanin FQ system attenuates alcohol withdrawal symptoms and reverses increased anxiety-like behavior associated with ethanol dependence (Economidou et al., 2011; Aujla et al., 2013). The gene discussed is PNOC; the disease is Anxiety.