In conclusion, despite the above-mentioned limitations, this meta-analysis suggests the TT genotype of rs1413711 and the C allele and the CC genotype of rs833061 in the VEGF-A gene are associated with an increased risk of overall AMD, and the TT genotype of rs1413711 and the C allele of rs833061 are a risk factor in wet AMD. The gene discussed is VEGFA; the disease is wet macular degeneration.