GH1 and Turner syndrome: The study presented here (NCT00699855; Merck Serono S.A., Study 28614: Observational Long-term Follow-up of the Phase IV Open-label Trial of Predictive Markers in Growth Hormone-Deficient and Turner Syndrome Pre-pubertal Children Treated with SAIZEN®) constitutes the first-year results following on from the PREDICT study, which uses a pharmacogenomic approach to evaluate the association of genetic polymorphisms in growth- and metabolism-related genes and baseline gene expression profiles using whole blood mRNA with long-term changes in growth while on r-hGH therapy.