Immunohistochemically, the tumor cells were diffusely positive for vimentin (Fig. 4A) and focally positive (cytoplasmic and dotlike) for neuron-specific enolase (NSE; Fig. 4B), S-100 (Fig. 4C) and epithelial membrane antigen (EMA; Fig. 4D). This evidence concerns the gene ENO2 and neoplasm.