Furthermore, an additional study from the Pandolfi’s group showed that PML plays an important pro-survival role in cancer via regulation of tumor cell metabolism [(Carracedo et al., 2012); for more extensive discussion on the role of PML in tumorigenesis, see comprehensive reviews in the field (Salomoni and Pandolfi, 2002), including this issue of Frontiers]. The gene discussed is PML; the disease is cancer.