Most DAXX and ATRX mutations are mutually exclusive and result in loss of expression (Elsasser et al., 2011; Heaphy et al., 2011; Jiao et al., 2011; Schwartzentruber et al., 2012; Wu et al., 2012), apart from a missense mutation found in acute myeloid leukemia (AML) (Ding et al., 2012). This evidence concerns the gene ATRX and acute myeloid leukemia.