AKT1 and plasma cell myeloma: Stimulation of human myeloma cells expressing TACI, BAFFR, and BCMA with BAFF or APRIL has also been shown to activate the PI3K-Akt pathway concomitant with protection against apoptosis (Moreaux et al., 2004); and lastly human adipose-derived stem cells additionally phosphorylated Akt after exposure to APRIL or BAFF (Zonca et al., 2012).