GJA1 and congenital heart disease: In contrast, 1 year later another very interesting study came to a radically opposed conclusion: in this study, 300 patients with conotruncal heart defects including Fallot’s Tetralogy were investigated and the authors discovered two silent mutations in the Cx43 gene in eight patients, but no mutations were found which would alter Cx43 amino acid sequence (Huang et al., 2011).