PARP-1 inhibitors have been effective in the treatment of ischemia/reperfusion damage after stroke or brain, myocardial, hepatic, and renal ischemia/reperfusion injury, other acute forms of cardiomyopathies and heart failure, tissue injury in response to septic and hemorrhagic shock, as well as acute lung inflammation, peritonitis, and pancreatitis. The gene discussed is PARP1; the disease is heart failure.