As a consequence of the results obtained in this study, we suggest that the simultaneous rather than the individual application of highly specific necroptosis and PARP-inhibitors (e.g., necrostatin and olaparib) may be the approach of choice for a future, improved treatment of necrosis-induced damage in diseases such as shock, stroke, or myocardial infarction. Here, PARP1 is linked to Stroke.