S100A4 and neoplasm: Statistically, S100A4 overexpression was closely associated with the tumor size (P=0.017), Lauren classification (P=0.002), histological classification (P=0.010), histological differentiation (P=0.000), Borrmann classification (P=0.020), TNM stage (P=0.000), LN metastasis (P=0.000) and distant metastasis (P=0.024).