Given that, in many patients, TIA may not become clinically apparent, it could be hypothesized that anti-PS/PT antibodies (present in a lupus patient with quiescent TIA) may lead, over time, to multiple infarcts or to subclinical cerebral flow disturbances, which can predispose to the development of other neuropsychiatric SLE features. This evidence concerns the gene PRB2 and systemic lupus erythematosus.