SMAD2 and breast cancer: Indeed, we identify a minimal overlap of four different network genes with the breast cancer signatures of Wang et al. (2005) (HDAC1, PIAS3) and van’t Veer et al. (2002) (DUSP4, DVL3) and a maximal overlap of 11 network genes with the ovarian cancer specific gene signature of Mok et al. (2009) (MAPK9, ARAF, PEPB1, MAPK1, TGFB3, ERBB2, ADAM12, GREM1, SMAD2, JAG2, GLI3).