Non-RTK-coupled signaling pathways have also been shown to affect mRNA decay in cancer cells such as the regulation of mRNA degradation in response to WNT signaling a mechanism that is under influence of signaling crosstalk by the PI3K/AKT pathway (Gherzi et al., 2006; Noubissi et al., 2006; Benjamin and Moroni, 2007). The gene discussed is PIK3CA; the disease is cancer.