MAPK8 and cancer: Furthermore, the mechanisms affecting mRNA degradation as mentioned above are either already known or highly likely to be regulated posttranslationally in the context of the proliferating cancer cell; for example protein phosphorylation downstream of ERK, JNK, or p38 signaling is relevant for regulation of mRNA decay while the molecular details of that regulation mechanism are not entirely analyzed yet (López de Silanes et al., 2007).