In a second experimental block cell lines with upregulated COX-2 expression were used, as like as human tumor cell lines (squamous cell carcinoma (FaDu) and colorectal adenocarcinoma (HT29)), mouse preadipocytes (3T3 L1) and 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated THP-1 and RAW 264.7 cells. This evidence concerns the gene PTGS2 and neoplasm.