PTGS2 and neoplasm: In detail, [18F]30 showed enhanced specific uptake in inflammatory sites induced by carrageenan in wild type Wistar rats and wild-type mice but not in COX-2 null mice and consistently, a specific uptake in COX-2 expressing 1483 HNSCC tumor xenografts but not in COX-2 negative HCT116 tumor xenografts [48].