Also, using the 18-radiolabeled COX-2 inhibitor [18F]30 on a carrageenan-induced inflammation model as well as on a 1483 HNSCC tumor model an uptake saturable by pre-administration with celecoxib, and hence specific uptake, could be demonstrated by the same authors [48]. This evidence concerns the gene PTGS2 and head and neck squamous cell carcinoma.