Of the EIF2AK3 mutations reported to date, four appeared to be associated with a specific phenotype: a delayed age of onset for diabetes was reported with the N656 and I650 mutations (3, 4, 31), whereas milder courses with prolonged survivals of 32 years and 35 years were reported with the F593 and L646 mutations, respectively (3, 4, 29). This evidence concerns the gene EIF2AK3 and diabetes mellitus.