EIF2AK3 and Wolcott-Rallison syndrome: Genetic diagnosis of WRS was confirmed in all 12 Saudi families (Table 1), and their affected members were homozygous for nine different EIF2AK3 mutations spreading through the PERK protein and leading to truncated proteins (4 nonsense, 4 frameshift, and one deletion at exon 14/intron boundaries of the EIF2AK3 gene).