Because the FOXP3 genetic variants rs2280883 and rs3761549 were significantly associated with susceptibility to HCC, further analysis was performed to determine the relationship between the FOXP3 genotype and multiple HCC clinical pathology variables, such as age, gender, alcohol abuse history, tumor size, tumor nodule, tumor grade, lymph node metastasis, portal vein tumor thrombus, distant metastasis and recurrence. This evidence concerns the gene FOXP3 and alcohol abuse.