It has been found that α2-adrenoreceptor agonist might attenuate the increase in plasma level of IL-1β, TNF-α and improve survival successfully after caecal ligation and puncture (CLP)-induced sepsis [43], and reduce the incidence of sepsis-induced AKI by decreasing TNF-α and MCP-1 [29]. The gene discussed is TNF; the disease is acute kidney injury.