BCL11A and large cell carcinoma: In this study, BCL11A gene copy number gains were frequently observed in squamous cell lung cancer patients, but not in adenocarcinoma or large cell carcinoma patients, which matched the results of Boelens et al. They observed that about 12% of squamous cell lung cancers had high copy number amplifications on chromosomal regions 2p15–p16.1, In addition, a significantly higher average expression level was observed for BCL11A in the SCC samples with amplifications as compared to SCC without amplifications.