SAMD9 and juvenile myelomonocytic leukemia: Lastly, the human SAMD9 and SAMD9L genes were both classified as myeloid tumor suppressors, as they are localized within a microdeletion cluster associated with myeloid disorders, such as juvenile myelomonocytic leukemia (JMML), acute myeloid leukemia (AML), and myelodysplastic syndrome (MDS)[2].