In addition, the over-expression of Nectin-2 in cell lines derived from various types of cancers (Figure 3) and in neuroblastoma, myeloid and lymphoblastic leukemias, gastric cancer, and colon cancer [27-29] suggests the possibility for the application of anti-Nectin-2 antibody to treat various cancer types. The gene discussed is NECTIN2; the disease is malignant colon neoplasm.