Although anti-Nectin-2 antibodies have been examined from a functional perspective, such as for the inhibition of Nectin-2 binding to DNAM-1, in vitro cell aggregation, or HSV-1 virion-induced cell fusion into host cells [6,18,21,22], there has been no report showing an anti-tumor effect of anti-Nectin-2 antibody. The gene discussed is NECTIN2; the disease is neoplasm.