The differences in the in vitro characteristics of Y-187 and Y-443 and the similarities in anti-tumor effects on OV-90 cells described above suggested that the anti-tumor effects of these 2 mAbs were not dependent on in vitro inhibitory activities against cell proliferation, Nectin-2-Nectin-2 interaction or Nectin-2-Nectin-3 interaction, but were most likely dependent on ADCC. This evidence concerns the gene NECTIN2 and neoplasm.