In vitro transcript profiling for PRL-modulated transcripts in another ER-positive human breast cancer cell line, MCF7, using Stat5 overexpression to enhance PRL effects, yielded 300 candidate PRL-modulated transcripts among which 12 overlapped with the panel identified in the present study of T47D cells (CISH, EGLN3, KCNK6, PTHrP, FN1, CHSY1, BCL6, DUSP4, IGFBP5, TNIK, ABCC4, and MYC) [17]. This evidence concerns the gene IGFBP5 and breast cancer.