Decreased serum Apo-A1 levels have been linked to increased incidence of cardiovascular disease [42] which, if the decrease in Apo-A1 that was observed in RLS/WED CSF was reflective of a global Apo-A1 level, this could be related to the increased risk for cardiovascular disease in RLS/WED [4-7]. Here, APOA1 is linked to cardiovascular disorder.