Tumour doubling time was prolonged from 4.67 days in mice receiving PBS, 6.12 days in mice receiving ATF, 6.43 days in mice receiving TPL to 9.05 days in mice receiving TPL + ATF (p < 0.05; CI = 1.36; Figure 7C), indicating a supra-additive or synergistic effect of TPL and ATF. The gene discussed is PLAU; the disease is neoplasm.