INS and diabetes mellitus: Before the advent of the consensus of the definition of the MS using International Diabetes Federation(IDF) [6], Experts from WHO and EGIR required the measurement of serum insulin levels, diabetes mellitus(DM) or glucose intolerance, hypertension, triglycerides, HDL-Cholesterol(C), body mass index(BMI), and waist circumference(WC) with different cutoff points [7,8].