When c-Myc shRNA vectors were transfected into 5-8F and 6-10B NPC cells, the mRNA expression of c-Myc decreased by 80% and 70% in 5-8F-Si-c-Myc and 6-10B-Si-c-Myc cells, respectively, as measured by semi-quantitative RT-PCR. This evidence concerns the gene MYC and nasopharyngeal carcinoma.