These correlations may stand to reason, given that ghrelin administration is considered as replacement therapy for underweight COPD patients who may be unable to compensate for the anabolic-catabolic imbalance, resulting in increasing the endogenous plasma acyl-ghrelin levels, thought repeated exogenous ghrelin might inhibit ghrelin production [31]. The gene discussed is GHRL; the disease is chronic obstructive pulmonary disease.