Deletions and mutations of TRAF3 have been reported in multiple myeloma [294-296], Waldenström’s macroglobulinemia [300], Hodgkin lymphomas (HLs) [301], and a variety of non-Hodgkin lymphomas (NHLs), including splenic marginal zone lymphoma, B cell chronic lymphocytic leukemia (B-CLL), and mantle cell lymphoma [298,299]. Here, TRAF3 is linked to B-cell chronic lymphocytic leukemia.