Unsupervised clustering performed on the filtered gene set (see material and methods) and based on DNAM1, NCR3(NKp30), CD96 and Class I–Restricted T-cell–Associated Molecule (CRTAM) expression signatures was able to spontaneously segregate the breast cancer patients in two distinct cohorts (Figure 1A). The gene discussed is CRTAM; the disease is breast carcinoma.