VEGF is the most potent mediator of angiogenesis (Carmeliet et al. 1996; Ng et al. 2001), and it plays a significant role in the pathophysiology of common respiratory disorders, including acute lung injury, asthma, COPD, pulmonary fibrosis, and lung cancer (Papaioannou et al. 2006). This evidence concerns the gene VEGFA and lung cancer.