However, decreased secretion of CCSP has been found in the lavage fluid of patients with asthma (Van Vyve et al. 1995), and polymorphisms in this gene that confer low serum levels of CCSP correlate with an increased risk of asthma in children with allergic rhinitis (Ku et al. 2011). This evidence concerns the gene SCGB1A1 and allergic rhinitis.