NF‐κB has been shown to regulate numerous genes involved in the initiation and progression of atherosclerosis, including genes involved in inflammation and immune cell regulation as well as apoptosis and cell proliferation.2–3 Genetic approaches have been utilized to identify the different mechanisms and cell type intrinsic actions of NF‐κB in mediating atherosclerosis and vascular inflammation. The gene discussed is NFKB1; the disease is atherosclerosis.