In an effort to assess in vivo the EC‐specific function of NF‐κB signaling in the pathogenesis of atherosclerosis, Gareus and colleagues generated several different mouse models employing either EC‐specific ablation of NEMO/IKKγ to interfere with IKK activation or transgenic expression of degradation resistant dominant negative IκBα superrepressor (DNIκBα). Here, NFKB1 is linked to atherosclerosis.