EP300 and atherosclerosis: During vascular inflammation and atherosclerosis in other cell types, such as ECs and macrophages, NF‐κB acts predominantly as a direct transcriptional activator via interaction with major coactivator proteins such as CREB‐binding protein (CBP), p300, steroid receptor‐coactivator‐1 (SRC‐1), and p300/CBP‐associated factor (PCAF).2–3,9 This apparent unique tissue‐specific transcriptional repression by NF‐κB in SMCs in response to vascular injury warrants further investigation to elucidate the detailed molecular mechanisms.